What causes lactic acidosis in kids?
What causes lactic acidosis in kids? Conditions that frequently lead to lactic acidosis include shock, sepsis, thiamine deficiency, diabetic ketoacidosis, and cellular poisoning (eg, cyanide toxicity). Why does Nrti cause lactic acidosis? Hepatic steatosis and lactic acidosis are thought to be caused by nucleoside reverse-transcriptase inhibitor (NRTI)–associated mitochondrial toxicity that results in inhibition of mitochondrial DNA γ-polymerase, which, in turn, impairs synthesis of mitochondrial enzymes that generate adenosine triphosphate [10]. What is the treatment for lactic acidosis? Intravenous administration of sodium bicarbonate has been the mainstay in the treatment of lactic acidosis. Aggressive use of this therapeutic modality, however, can...