What is dopamine beta-hydroxylase deficiency?
What is dopamine beta-hydroxylase deficiency? Dopamine beta (β)-hydroxylase deficiency is a condition that affects the autonomic nervous system, which controls involuntary body processes such as the regulation of blood pressure and body temperature. Problems related to this disorder can first appear during infancy. What is DBH deficiency? Dopamine beta-hydroxylase (DBH) deficiency is characterized by lack of sympathetic noradrenergic function but normal parasympathetic and sympathetic cholinergic function. Affected individuals exhibit profound deficits in autonomic regulation of cardiovascular function that predispose to orthostatic hypotension. Where is dopamine beta-hydroxylase found? Dopamine Beta-Hydroxylase DBH is localized inside the chromaffin granules of adrenal medullary cells...