How do zinc fingers recognize DNA?
How do zinc fingers recognize DNA? Zinc fingers bind in the major groove of the DNA, wrapping around the strands, with specificity conferred by side chains of several amino acid on the α helices. Some zinc finger proteins undergo homodimerization by hydrophobic interactions or by finger-finger binding and reinforce the specific binding to DNA. What are the roles of DNA in bent finger? DNA structural changes such as bending play an important role in various biological reactions. Such DNA-bending fingers may be feasible for use as a gene expression regulator based on the structural change in DNA in the future....