How much nortriptyline is lethal?
How much nortriptyline is lethal? HumanDrugReported fatal doseProbable oral fatal doseNortriptyline5 (Extremely toxic)5–50 mg kg−1Protriptyline5 (Extremely toxic)5–50 mg kg−1Imipramine4 (Very toxic)50–500 mg kg−1Doxepin4 or 5 (very to extremely toxic)50–500 or 5–50 mg kg−1 Why are tricyclic antidepressants so toxic in overdose? TCAs are rapidly absorbed in the gastrointestinal tract. However, following an overdose, owing to the inherent anticholinergic effects, TCAs may decrease the gastrointestinal motility and cause delayed absorption and toxicity. Coingestion of other anticholinergic medications may cause more erratic absorption. What happens if you take too much nortriptyline? An overdose of nortriptyline can be fatal. Overdose symptoms may include...