What does the beta-3 receptor do?
What does the beta-3 receptor do? β-3 Adrenergic receptors are found on the cell surface of both white and brown adipocytes and are responsible for lipolysis, thermogenesis, and relaxation of intestinal smooth muscle. What receptors stimulate lipolysis? Lipolysis is triggered by the activation of adenyl cyclase, which converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP). Catecholamines, acting via beta-adrenergic receptors (βADRs), stimulate adenyl cyclase but this action is counteracted by activation of alpha-adrenergic receptor (αADR). What does a beta-3 agonist do? Mirabegron is a beta-3 adrenergic receptor agonist that causes relaxation of the detrusor smooth muscle of the urinary...