What will happen if protein kinase undergoes mutation?
What will happen if protein kinase undergoes mutation? Kinase mutations may activate proliferative pathways, causing genomic instability by abrogating cell cycle checkpoints, inhibit or abolish DNA damage response, deactivate apoptotic pathways, and/or promote angiogenesis and cell motility. What is a cancer driver mutation? A driver mutation is an alteration that gives a cancer cell a fundamental growth advantage for its neoplastic transformation. It differs from passenger mutations in that these do not necessarily determine the development of the cancer. Do driver mutations initiate cancer? A driver mutation is causally implicated in oncogenesis. It has conferred growth advantage on the cancer...