How do you permeabilize cells for immunofluorescence?
How do you permeabilize cells for immunofluorescence? PermeabilizationIncubate the samples for 10 min with PBS containing either 0.1–0.25% Triton X-100 (or 100 μM digitonin or 0.5% saponin). The optimal percentage of Triton X-100 should be determined for each protein of interest.Wash cells in PBS three times for 5 min. How do you permeabilize cells for staining? Permeabilizing the cells through methanol or acetone fixation, or with the use of a detergent, allows antibodies to pass through the cellular membrane and enter the cell. The most common reagent used for cell permeabilization is non-ionic detergent, Triton X-100. Can you do immunofluorescence...