What is hot melt extrusion in pharmaceutical industry?
What is hot melt extrusion in pharmaceutical industry? Hot melt extrusion (HME) is the process of applying heat and pressure to melt a polymer and forcing it through an orifice in a continuous process. HME is well-known, developed to produce polymer products of uniform shape and density, and its industrial application dates back to the 1930s1. What is melt extrusion technology? The melt extrusion process consists of melting the polymer pellets through a combination of applied heat and friction. This molten polymer is then forced under high pressure through a small orifice or, more typically, a “shower head” of orifices...